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gp1ba

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Official Full Name
glycoprotein Ib (platelet), alpha polypeptide
Background
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.
Synonyms
BSS; GP1B; CD42B; mgC34595; CD42b-alpha; GP1BA; platelet glycoprotein Ib alpha chain; GPIbA GP-Ib alpha antigen CD42b-alpha platelet membrane glycoprotein 1b-alpha subunit; glycoprotein Ib (platelet), alpha polypeptide; GP-Ib alpha; antigen CD42b-alpha; platelet membrane glycoprotein 1b-alpha subunit; VWDP; GPIbA; BDPLT1; BDPLT3; DBPLT3