The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
GGCT; gamma-glutamylcyclotransferase; C7orf24, chromosome 7 open reading frame 24 , GCTG; CRF21; Ggc; MGC3077; cytochrome c-releasing factor 21; gamma -glutamyl cyclotransferase; GCTG; C7orf24; FLJ11717; C7orf24, CRF21, FLJ11717, GCTG, GGC, MGC3077, GGCT