Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene.
GFRA1; GDNF family receptor alpha 1; GDNFRA; GDNF family receptor alpha-1; GDNFR; GFR ALPHA 1; RET1L; RETL1; TRNR1; GDNF R; GDNF receptor alpha; GDNFR alpha; GDNFRalpha; GFR-ALPHA-1; GFRalpha1; Glial cell line-derived neurotrophic factor receptor alpha; GPI linked anchor protein; GPI-linked anchor protein; MGC23045; PI linked cell surface accessory protein; RET ligand 1; TGF-beta related neurotrophic factor receptor 1; TRNR 1; GDNFR-alpha-1; OTTHUMP00000020558; OTTHUMP00000020559; OTTHUMP00000020560; GDNF receptor alpha-1; PI-linked cell-surface accessory protein; TGF-beta-related neurotrophic factor receptor 1; FLJ10561; FLJ31546; DKFZp313E1012; DKFZp686J0156; GDNFR, RET1L, RETL1, TRNR1, GDNFRA, MGC23045, GFR-ALPHA-1