This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described.
GCNT2; glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group); cataract, congenital , CCAT, GCNT5, glucosaminyl (N acetyl) transferase 2, I branching enzyme , glucosaminyl (N acetyl) transferase 2, I branching enzyme (Ii blood group) , glucosaminyl (N acetyl) transferase 5 , II, NACGT1; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase; bA360O19.2; bA421M1.1; IGNT; Ii blood group; NAGCT1; ULG3; unassigned linkage group 3; Beta 1 6 N acetylglucosaminyltransferase 2; CCAT; GCNT 2; GCNT2C; GCNT5; Glucosaminyl (N acetyl) transferase 2 I branching enzyme (I blood group); Glucosaminyl (N acetyl) transferase 2 I branching enzyme; I beta 1 6 N acetylglucosaminyltransferase; I branching beta 1 6 acetylglucosaminyltransferase; I branching enzyme; II; MGC163396; N acetylglucosaminyltransferase; N acetyllactosaminide beta 1 6 N acetylglucosaminyltransferase; NACGT1; I-branching enzyme; OTTHUMP00000016015; OTTHUMP00000016018; OTTHUMP00000016021; N-acetylglucosaminyltransferase; I beta-1,6-N-acetylglucosaminyltransferase; beta-1,6-N-acetylglucosaminyltransferase 2; I-branching beta-1,6-acetylglucosaminyltransferase; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase