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fus

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Official Full Name
FUS RNA binding protein
Background
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]
Synonyms
FUS; fused in sarcoma; TLS; ALS6; ETM4; FUS1; POMP75; HNRNPP2; RNA-binding protein FUS; oncogene FUS; oncogene TLS; fus-like protein; 75 kDa DNA-pairing protein; fusion gene in myxoid liposarcoma; translocated in liposarcoma protein; heterogeneous nuclear ribonucleoprotein P2; ALS6, amyotrophic lateral sclerosis 6 , fusion (involved in t(12; 16) in malignant liposarcoma) , fusion, derived from t(12; 16) malignant liposarcoma; hnRNP P2; translocated in liposarcoma; FUS/TLS; fusion; pigpen; FUS RNA binding protein; zgc:56390; fusion (involved in t(12; 16) in malignant liposarcoma)

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