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frem2

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Official Full Name
FRAS1 related extracellular matrix protein 2
Background
This gene encodes an integral membrane protein containing numerous CSPG (chondroitin sulfate proteoglycan element) repeats and Calx-beta domains. The encoded protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions. This protein is important for the integrity of skin and renal epithelia. Mutations in this gene are associated with Fraser syndrome. [provided by RefSeq, Apr 2014]
Synonyms
FREM2; FRAS1 related extracellular matrix protein 2; FRAS1-related extracellular matrix protein 2; ECM3 homolog