This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene.
FLNC; filamin C, gamma; filamin C, gamma (actin binding protein 280) , FLN2; filamin-C; ABP 280; ABPL; actin binding protein 280; ABP L; Actin binding like protein; Filamin 2; Filamin C; Filamin C gamma; FLJ10186; FLN 2; FLN2; Gamma actin binding protein; Gamma filamin; Protein FLNc; FLN-C; filamin-2; ABP-280-like protein; ABP-L, gamma filamin; actin-binding-like protein; ABPA; MFM5; MPD4; ABP-280; ABP280A; 260kDa actin-binding protein; cgABP260 actin-binding domain