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fgf23

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Official Full Name
fibroblast growth factor 23
Background
This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013]
Synonyms
FGF23; fibroblast growth factor 23; ADHR; FGFN; HYPF; HPDR2; PHPTC; phosphatonin; tumor-derived hypophosphatemia inducing factor

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