Fc receptor homologs (FcRH5), also known as IRTA2 proteins, are transmembrane proteins with sequence homology to classical Fc receptor families. FcRH5 function as activating or inhibitory receptors on discrete B cell populations and are involved in B-cell development and differentiation in peripheral lymphoid organs. FcRH5 expression is deregulated in multiple myeloma and Burkitt lymphoma cell lines with 1q21 abnormalities. FcRH5 may play a critical role for the pathogenesis of B-cell lymphoma.
FCRL5; Fc receptor-like 5; Fc receptor-like protein 5; BXMAS1; CD307e; FCRH5; IRTA2; fcR-like protein 5; fc receptor homolog 5; immune receptor translocation-associated protein 2; immunoglobulin superfamily receptor translocation associated 2 (IRTA2); CD307; PRO820; FLJ00333; FLJ00397; RP11-217A12.1; MGC119590; MGC119592; MGC119593; DKFZp667F216; DKFZp667E2019