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fcgr1a

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Official Full Name
Fc fragment of IgG, high affinity Ia, receptor (CD64)
Background
CD64 is the high-affinity IgG Fc receptor belonging to the immunoglobulin supergene family (Guyre, 2002). CD64 is a 72 kDa glycoprotein which binds monomeric IgG (human IgG1>IgG3>>IgG4>>>IgG2 and mouse IgG3>IgG2a>>>IgG1, IgG2b). Three genes: FcgammaR1A, FcgammaR1B and FcgammaR1C, which have >98 percent identity at the nucleotide level, have been identified and mapped to chromosome 1, band q21.1 (Sun,1997)). The FcgammaR1A gene, which specified the high-affinity IgG receptor, encodes three C2-type Ig-like extracellular domains, a 21 amino acid transmembrane region, and a charge cytoplasmic tail of 61 amino acids (Sun, 1997)(van de Winkel,1993).
Synonyms
FCGR1A; Fc fragment of IgG, high affinity Ia, receptor (CD64); high affinity immunoglobulin gamma Fc receptor I; Fc receptor, IgG, high affinity I; high affinity IgG Fc receptor, subunit beta; Fc fragment of IgG high affinity Ib receptor; high-affinity immunoglobulin gamma Fc receptor I; Fc fragment of IgG, high affinity Ib, receptor for (CD64); Fcgr1; Fcgr1b; FcgammaRI; Fc fragment of IgG, high affinity Ia, receptor for (CD64); CD64; CD64A; fcgammaRIa; Fc-gamma RI; fc-gamma RIA; Fc gamma receptor; IgG Fc receptor I; Fc-gamma receptor I A1; FCRI; IGFR1; FLJ18345

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