This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
FCAR; Fc fragment of IgA, receptor for; immunoglobulin alpha Fc receptor; CD89; Fc alpha receptor; FCAR_HUMAN; IgA Fc receptor; OTTHUMP00000068691; OTTHUMP00000068692; OTTHUMP00000068693; OTTHUMP00000068694; OTTHUMP00000068695; OTTHUMP00000068696; OTTHUMP00000068697; OTTHUMP00000068698