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fbxo18

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Official Full Name
F-box protein, helicase, 18
Background
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
Synonyms
FBXO18; F-box protein, helicase, 18; F box only protein 18; F-box only protein 18; FBH1; Fbx18; FLJ14590; F-box DNA helicase 1; F-box only protein, helicase, 18; MGC131916; MGC141935; MGC141937; F-box helicase; si:dkey-22l11.2