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Official Full Name
F-box and leucine-rich repeat protein 8
Background
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. It shares 78% sequence identity with the mouse protein.
Synonyms
FBXL8; F-box and leucine-rich repeat protein 8; F-box/LRR-repeat protein 8; Fbl8; F box and leucine rich repeat protein 8; F box protein FBL8; F box/LRR repeat protein 8; FBL 8; Fbxl 8; F-box protein FBL8; FLJ11278; MGC19959; zgc:123259

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