This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
FBXL2; F-box and leucine-rich repeat protein 2; F-box/LRR-repeat protein 2; FBL2; FBL3; DKFZP564P0622; F box and leucine rich repeat protein 2; F-box protein containing leucine-rich repeats; F-box protein FBL2/FBL3; FBL 2; FBL 3; FBXL 2; fbxl20; sb:cb783; zgc:73374; F-box and leucine-rich repeat protein 20