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etv6

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Official Full Name
ets variant 6
Background
This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008]
Synonyms
ETV6; ets variant 6; TEL; TEL/ABL; transcription factor ETV6; TEL1 oncogene; ETS-related protein Tel1; ETS translocation variant 6; ets variant gene 6 (TEL oncogene); TEL oncogene; ets domain protein; id:ibd2308; ztel