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etf1

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Official Full Name
eukaryotic translation termination factor 1
Background
This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013]
Synonyms
ETF1; eukaryotic translation termination factor 1; ERF; RF1; ERF1; TB3-1; D5S1995; SUP45L1; eukaryotic peptide chain release factor subunit 1; protein Cl1; polypeptide chain release factor 1; sup45 (yeast omnipotent suppressor 45) homolog-like 1; ERF, ERF1, SUP45L1; sup45 (yeast omnipotent suppressor 45) homolog like 1; TB3 1; eukaryotic release factor 1; MGC111066