This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis.
ESX1; ESX homeobox 1; ESX1L, extraembryonic, spermatogenesis, homeobox 1 homolog (mouse); homeobox protein ESX1; ESXR1; homeobox 1; spermatogenesis; Epx; ESX1_HUMAN; ESX1L; Etx; Extraembryonic; Extraembryonic spermatogenesis homeobox 1; Homeobox protein ESX1-C; Spx1; ESX1-related protein; extraembryonic, spermatogenesis, homeobox 1 homolog