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espl1

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Official Full Name
extra spindle pole bodies homolog 1 (S. cerevisiae)
Background
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for;chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The;first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second;step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the;final separation of sister chromatids (Sun et al., 2009 (PubMed 19345191)).
Synonyms
ESPL1; extra spindle pole bodies homolog 1 (S. cerevisiae); extra spindle poles like 1 (S. cerevisiae); separin; ESP1; KIAA0165; SEPA; separase; caspase-like protein ESPL1; extra spindle poles like 1; extra spindle poles-like 1 protein; FLJ46492

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