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Official Full Name
epithelial cell adhesion molecule
Background
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.
Synonyms
EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; antigen identified by monoclonal antibody AUA1; tumor-associated calcium signal transducer 1; 17-1A; 323/A3; CD326; CO-17A; EGP34; GA733-2; HEA125; Ly74; MH99; MOC31; TACST-1; Adenocarcinoma-associated antigen; Cell surface glycoprotein Trop-1; Epithelial cell surface antigen; Epithelial glycoprotein; Epithelial glycoprotein 314; KS 1/4 antigen; Major gastrointestinal tumor-associated protein GA733-2; human epithelial glycoprotein-2; Ep-CAM; membrane component, chromosome 4, surface marker (35kD glycoprotein); EGP; M1S2; CD326 antigen; Hegp314; ACSTD1; Adecatumumab; 503605-66-1; Citatuzumab bogatox; 945228-49-9; Tucotuzumab celmoleukin; 339986-90-2; Solitomab; sb:cb6; tacstd; zgc:77119; wu:fj17g02; zgc:110304; pan-epithelial glycoprotein; tumor-associated calcium signal transducer