The protein encoded by this gene has a C-terminal domain with tRNA 3&#8242; processing endoribonuclease activity, which catalyzes the removal of the 3 trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
ELAC2; elaC homolog 2 (E. coli); elaC (E. coli) homolog 2; zinc phosphodiesterase ELAC protein 2; FLJ10530; HPC2; tRNase Z (long form); ElaC homolog protein 2; ELC2; FLJ36693; FLJ42848; Heredity prostate cancer protein 2; putative prostate cancer susceptibility protein HPC2/ELAC2; Ribonuclease Z 2; Ribonuclease Z2; RNase Z 2; RNase Z2; RNZ2_HUMAN; tRNA 3 endonuclease 2; tRNase Z 2; tRNase Z2; elaC ribonuclease Z 2; im:7145112; elaC homolog 2