Official Full Name
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Eukaryotic translation initiation factor 2 subunit 1?is a?protein?that in humans is encoded by the?EIF2S1?gene. Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
EIF2S1; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa; EIF2; EIF-2; EIF2A; EIF-2A; EIF-2alpha; eukaryotic translation initiation factor 2 subunit 1; eIF-2-alpha; OTTHUMP00000028404; OTTHUMP00000218025; eukaryotic translation initiation factor 2 subunit alpha