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eef2

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Official Full Name
eukaryotic translation elongation factor 2
Background
eEF2 (eukaryotic translation elongation factor 2) is essential for protein synthesis. It promotes the GTP-dependent translocation during peptide chain elongation. eEF2 is phosphorylated and inhibited by eEF2 kinase (eEF2K) on Thr56. eEF2K activity is inhibited by phosphorylation by both mTOR and p70S6K. This in turn up regulates eEF2 activity and protein synthesis. Similarly, AMPK down regulates protein synthesis by inhibited the activity of both p70S6K and mTOR, through TSC2.
Synonyms
EEF2; eukaryotic translation elongation factor 2; EF2; elongation factor 2; EEF 2; polypeptidyl tRNA translocase; polypeptidyl-tRNA translocase; EF-2; EEF-2; EF2, EF-2, EEF-2