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edg8

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Official Full Name
sphingosine-1-phosphate receptor 5
Background
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.
Synonyms
S1PR5; sphingosine-1-phosphate receptor 5; EDG8, endothelial differentiation, sphingolipid G protein coupled receptor, 8; sphingosine 1-phosphate receptor 5; Edg 8; S1P receptor 5; S1P receptor Edg-8; sphingosine 1-phosphate receptor EDG8; sphingosine 1-; sphingosine 1-phosphate receptor Edg-8; endothelial differentiation G-protein-coupled receptor 8; endothelial differentiation, sphingolipid G-protein-coupled receptor, 8; EDG8; S1P5; Edg-8; SPPR-1; SPPR-2