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e4f1

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Official Full Name
E4F transcription factor 1
Background
The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.
Synonyms
E4F1; E4F transcription factor 1; transcription factor E4F1; E4F; E4F transcription factor 1, isoform CRA_b; P120E4F transcription factor; p50E4F; p120E4F; transcription factor E4F; putative E3 ubiquitin-protein ligase E4F1; MGC99614; zgc:114190

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