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duox1

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Official Full Name
dual oxidase 1
Background
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX2. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.
Synonyms
DUOX1; dual oxidase 1; flavoprotein NADPH oxidase; LNOX1; NADPH thyroid oxidase 1; nicotinamide adenine dinucleotide phosphate oxidase; NOXEF1; THOX1; Dual oxidase 1 precursor; EC 1.11.1; EC 1.6.3.1; Large NOX 1; Long NOX 1; MGC138840; MGC138841; Thyroid oxidase 1

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