Defects in kinetochore proteins often lead to aneuploidy and cancer. Mis12-Ktw1 is a conserved essential kinetochore protein family. Human Mis13 protein (c20orf172) is one of the several proteins that form Mis12-kinetochore complex and required for chromosome segregation. Mis13 protein also physically interacts with Blinkin/AF15q14 which is required for mitotic checkpoint and chromosome alignment. It is also required for condensin to accumulate at kinetochores.
DSN1; DSN1, MIND kinetochore complex component, homolog (S. cerevisiae); C20orf172, chromosome 20 open reading frame 172; kinetochore-associated protein DSN1 homolog; dJ469A13.2; hKNL 3; kinetochore null 3 homolog (C. elegans); KNL3; MIS13; kinetochore null 3 homolog; hKNL-3; C20orf172; FLJ13346; MGC32987; DSN1, MIS12 kinetochore complex component; DSN1, MIND kinetochore complex component, homolog