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drap1

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Official Full Name
DR1-associated protein 1 (negative cofactor 2 alpha)
Background
Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans.Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex.
Synonyms
DRAP1; DR1-associated protein 1 (negative cofactor 2 alpha); dr1-associated corepressor; DR1 associated corepressor; NC2 alpha; negative cofactor 2 alpha; DR1 associated protein 1 (negative cofactor 2 alpha); DR1 associated protein 1; DR1 associated protein1; DRAP 1; NC 2 alpha; NC 2alpha; Negative cofactor 2alpha; OTTHUMP00000234061; OTTHUMP00000234062; OTTHUMP00000234063; OTTHUMP00000234065; OTTHUMP00000234066; negative co-factor 2-alpha; NC2-alpha; fb26e10; zgc:56003; zgc:77337; wu:fb26e10