Official Full Name
down-regulator of transcription 1, TBP-binding (negative cofactor 2)
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
DR1; down-regulator of transcription 1, TBP-binding (negative cofactor 2); protein Dr1; NC2; NC2 BETA; Dr1 protein; Negative cofactor 2 beta; Downregulator of transcription 1; Down regulator of transcription 1 TBP binding; DR 1; NC 2; Negative co factor 2; Negative cofactor 2; TATA binding protein associated phosphoprotein; OTTHUMP00000012556; OTTHUMP00000012557; negative cofactor 2-beta; TATA-binding protein-associated phosphoprotein; NC2-BETA; NC2, NC2-BETA; down-regulator of transcription 1; wu:fj15f04; zgc:152914