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dpp6

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Official Full Name
dipeptidyl-peptidase 6
Background
This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Synonyms
DPP6; dipeptidyl-peptidase 6; VF2; DPPX; dipeptidyl aminopeptidase-like protein 6; DPP VI; dipeptidylpeptidase 6; dipeptidyl peptidase VI; dipeptidyl peptidase IV-related protein; dipeptidyl aminopeptidase IV-related protein