This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternate transcriptional splice variants have been characterized.
DPP3; dipeptidyl-peptidase 3; dipeptidylpeptidase 3 , dipeptidylpeptidase III; dipeptidyl peptidase 3; Dipeptidyl aminopeptidase III; Dipeptidyl arylamidase III; Dipeptidyl peptidase III; DPP III; DPP3_HUMAN; EC 220.127.116.11; dipeptidylpeptidase 3; dipeptidylpeptidase III; DPPIII; FLJ11387; FLJ22331; zgc:86791; wu:fb64b04