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dph5

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Official Full Name
diphthamide biosynthesis 5
Background
This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms
DPH5; DPH5 homolog (S. cerevisiae); diphthine synthase; CGI 30; AD 018; AD018; CGI30; Diphthamide biosynthesis methyltransferase; NPD015; Protein x 0011; AD-018; CGI-30; HSPC143; MGC61450; diphthamide biosynthesis 5; zgc:101823; DPH5 homolog