Official Full Name
deoxyribonuclease II beta
The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene.
DNASE2B; deoxyribonuclease II beta; deoxyribonuclease-2-beta; DLAD; Deoxyribonuclease 2 beta; Deoxyribonuclease 2 beta precursor; DNase 2 like acid DNase; DNASE 2B; DNase II beta; DNase II like acid DNase; DNASE2; DNase2 like acid DNase; DnaseIIb; EC 18.104.22.168; Endonuclease DLAD; Lysosomal DNase II; UOX; DNase2-like acid DNase; DNase II-like acid DNase