Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones.
DHRS4; dehydrogenase/reductase (SDR family) member 4; dehydrogenase/reductase SDR family member 4; FLJ11008; humNRDR; SCAD SRL; SDR SRL; SDR25C2; short chain dehydrogenase/reductase family 25C; member 2; mouNRDR; NDRD; RRD; AI043103; AI790593; Carbonyl reductase; CR; D14Ucla2; DHRS4_HUMAN; NADPH dependent carbonyl reductase/NADP retinol dehydrogenase; NADPH dependent retinol dehydrogenase/reductase; NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; NADPH-dependent retinol dehydrogenase/reductase; NRDR; Peroxisomal short chain alcohol dehydrogenase; Peroxisomal short-chain alcohol dehydrogenase; PHCR; PRO1800; PSCD; SCAD-SRL; SCADSRL; Short chain dehydrogenase/reductase family member 4; Short-chain dehydrogenase/reductase family member 4; UNQ851; NADP-dependent retinol dehydrogenase; dehydrogenase/reductase (SDR family) member 4 like 2A; short chain dehydrogenase/reductase family 25C, member 1; short chain dehydrogenase/reductase family 25C, member 2; SDR-SRL; SDR25C1; DHRS2; rabNRDR