The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
DERL3; Der1-like domain family, member 3; C22orf14, chromosome 22 open reading frame 14; derlin-3; derlin 3; FLJ43842; IZP6; MGC71803; C22orf14; Degradation in endoplasmic reticulum protein 3; DER 3; Der1 like domain family member 3; Der1 like protein 3; Der1-like protein 3; DER3; DERL 3; DERL3_HUMAN; Derlin 3 protein; Derlin3; DERtrin 3; DERtrin-3; DERtrin3; IZP 6; LLN 2; LLN2; zgc:63991