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dedd2

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Official Full Name
death effector domain containing 2
Background
Death effector domain-containing protein is a protein that in humans is encoded by the DEDD gene. This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene.
Synonyms
DEDD2; death effector domain containing 2; FLAME-3; DNA-binding death effector domain-containing protein 2; DED-containing protein FLAME-3; FADD-like anti-apoptotic molecule 3; death effector domain-containing DNA binding protein 2; FLAME 3