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ddx18

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Official Full Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
Background
DDX18 protein (670aa 75.4KDa) is a putative ATP-dependent RNA helicase since it possesses a DEAD box motif characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD).RNA helicases which may play a role in ribosome biogenesis. DDX18 acts as a cofactor for XPO1-mediated nuclear export of incompletely spliced HIV-1 Rev RNAs. It was also involved in HIV-1 replication and interacts specifically with hepatitis C virus core protein resulting in a change in intracellular location.
Synonyms
DDX18; DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 18 (Myc regulated); ATP-dependent RNA helicase DDX18; MrDb; DEAD box protein 18; Myc-regulated DEAD box protein; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 18 (Myc-regulated); FLJ33908; cb155; sb:cb155; wu:fa19d11; fa19d11

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