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dab2

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Official Full Name
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
Background
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Synonyms
DAB2; Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila); DOC2; DOC-2; disabled homolog 2; differentially-expressed protein 2; disabled homolog 2, mitogen-responsive phosphoprotein; disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila); disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein); DOC 2; FLJ26626; DOC2, DOC-2; sb:cb778; zgc:77136; Dab, mitogen-responsive phosphoprotein, homolog 2