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cyp17a1

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Official Full Name
cytochrome P450, family 17, subfamily A, polypeptide 1
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
Synonyms
CYP17A1; cytochrome P450, family 17, subfamily A, polypeptide 1; CYP17, cytochrome P450, subfamily XVII (steroid 17 alpha hydroxylase), adrenal hyperplasia; steroid 17-alpha-hydroxylase/17,20 lyase; CPT7; P450C17; S17AH; Steroid 17 alpha monooxygenase; 20 lyase; CP17A_HUMAN; CYP17; CYPXVII; Cytochrome P450 17A1; Cytochrome P450 family 17; Cytochrome P450 family 17 subfamily A polypeptide 1; Cytochrome p450 XVIIA1; Cytochrome p450, subfamily XVII (steroid 17 alpha hydroxylase) adrenal hyperplasia; Cytochrome P450-C17; Cytochrome P450c17; OTTHUMP00000020382; P450 C17; Steroid 17 alpha hydroxylase/17,20 lyase; Steroid 17-alpha-hydroxylase/17; Steroid 17-alpha-monooxygenase; cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia; RP11-753C18.1; P450-C17; 17-alpha-hydroxyprogesterone aldolase; zgc:66494; wu:fi13g04; wu:fi17b11; wu:fi31c08; zgc:136516

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