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cul4b

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Official Full Name
cullin 4B
Background
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms
CUL4B; cullin 4B; cullin-4B; CUL-4B; SFM2; MRXSC; MRXHF2; MRXS15; KIAA0695; DKFZp686F1470; DKFZp686F1470, KIAA0695, MRXHF2, MRXS15, MRXSC, SFM2, CUL4B; im:7140950; im:7150765