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ctsd

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Official Full Name
cathepsin D
Background
This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008]
Synonyms
CTSD; cathepsin D; CPSD; CLN10; HEL-S-130P; lysosomal aspartyl protease; lysosomal aspartyl peptidase; ceroid-lipofuscinosis, neuronal 10; epididymis secretory sperm binding protein Li 130P; cathepsin D (lysosomal aspartyl protease) , CPSD; ceroid lipofuscinosis; neuronal 10; MGC2311; prepro-cathepsin D, prepro-CD; cathepsin D (lysosomal aspartyl protease); cathepsin D (lysosomal aspartyl peptidase); catD; fb93e11; fj17b09; wu:fb93e11; wu:fj17b09; etID16901.18