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ctnnd2

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Official Full Name
catenin (cadherin-associated protein), delta 2
Background
This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome.
Synonyms
CTNND2; catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein); catenin delta-2; GT24; NPRAP; Catenin (cadherin associated protein) delta 2; Catenin delta 2; CTND2_HUMAN; CTNND 2; Delta catenin; Delta-catenin; GT 24; Neural plakophilin related arm repeat protein; Neural plakophilin related armadillo repeat protein; Neural plakophilin-related ARM-repeat protein; Neurojungin; OTTHUMP00000115594; OTTHUMP00000220687; OTTHUMP00000220689; OTTHUMP00000220690; T-cell delta-catenin