This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent;gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein;encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A;translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein,;has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that;encode different protein isoforms.