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cpz

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Official Full Name
carboxypeptidase Z
Background
Chlorpromazine (as chlorpromazine hydrochloride, abbreviated CPZ) is a typical antipsychotic. Chlorpromazine works on a variety of receptors in the central nervous system, producing anticholinergic, antidopaminergic, antihistaminic, and weak antiadrenergic effects. Both the clinical indications and side effect profile of CPZ are determined by this broad action: its anticholinergic properties cause constipation, sedation, and hypotension, and help relieve nausea. It also has anxiolytic (anxiety-relieving) properties. Its antidopaminergic properties can cause extrapyramidal symptoms such as akathisia (restlessness, aka the 'largactil shuffle' where the patient walks almost constantly, despite having nowhere to go due to mandatory confinement, and takes small, shuffling steps) and dystonia. It is known to cause tardive dyskinesia, which can be irreversible.
Synonyms
CPZ; carboxypeptidase Z; metallocarboxypeptidase Z; MGC99682; cCPZ