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cox17

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Official Full Name
COX17 cytochrome c oxidase copper chaperone
Background
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13.
Synonyms
COX17; COX17 cytochrome c oxidase assembly homolog (S. cerevisiae); COX17 (yeast) homolog, cytochrome c oxidase assembly protein , COX17 homolog, cytochrome c oxidase assembly protein (S. cerevisiae) , COX17 homolog, cytochrome c oxidase assembly protei; COX17 (yeast) homolog, cytochrome c oxidase assembly protein , COX17 homolog, cytochrome c oxidase assembly protein (S. cerevisiae) , COX17 homolog, cytochrome c oxidase assembly protein (yeast); cytochrome c oxidase copper chaperone; human homolog of yeast mitochondrial copper recruitment; MGC104397; MGC117386; COX17 cytochrome c oxidase copper chaperone; COX17 cytochrome c oxidase assembly homolog; zgc:103765; zgc:191605; COX17 homolog, cytochrome c oxidase assembly protein

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