Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both;eukaryotes and prokaryotes (Jonassen and Clarke, 2000 (PubMed 10777520)). This lipid consists of a hydrophobic;isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to;anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the;respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic;pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic;acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene;product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl;phenol.
COQ3; coenzyme Q3 homolog, methyltransferase (S. cerevisiae); coenzyme Q3 homolog, methyltransferase (yeast); hexaprenyldihydroxybenzoate methyltransferase, mitochondrial; bA9819.1; polyprenyldihydroxybenzoate methyltransferase; DHHB-MT; DHHB-MTase; DHHB; DHHB methyltransferase; methyltransferase COQ3; 2-polyprenyl-6-hydroxyphenyl methylase; 3-demethylubiquinone-10 3-methyltransferase; dihydroxyhexaprenylbenzoate methyltransferase; 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase; DHHBMT; DHHBMTASE; UG0215E05; coenzyme Q3 methyltransferase; fb14b06; fl80g11; zgc:92256; wu:fb14b06; wu:fl80g11; coenzyme Q3 homolog, methyltransferase