Type II collagen is the major collagen found in cartilage and is expressed in two forms: IIA and IIB. Type IIA procollagen contains an N-terminal 69 amino acid, cysteine-rich globular domain that is encoded by exon 2. Type IIB procollagen is synthesized by mature chondrocytes in cartilage while Type IIA procollagen is synthesized by chondroprogenitor cells. The Type IIA N-propeptide (PIIANP) has been postulated to play a role in chondrogensis. Type IIA procollagen has been found to be synthesized by osteoarthritic chondrocytes in diseased cartilage and may serve as a specific arthritis biomarker that reflects an attempt by the chondrocytes to repair diseased cartilage.
ANFH; AOM; COL11A3; SEDC; alpha-1 type II collagen; cartilage collagen; chondrocalcin; collagen II, alpha-1 polypeptide; collagen alpha-1(II) chain; COL2A1; collagen, type II, alpha 1; collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) , SEDC; MGC131516; procollagen alpha 1(II); alpha 1 type IIA collagen; alpha 1 type II procollagen; collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, co