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cobra1

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Official Full Name
cofactor of BRCA1
Background
NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or;NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a;heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA;polymerase II (see MIM 180660) (Narita et al., 2003 (PubMed 12612062)).
Synonyms
COBRA1; cofactor of BRCA1; negative elongation factor B; KIAA1182; NELF B; A730008L03Rik; AB041607; DKFZp586B0519; AI663983; Negative elongation factor protein B; NELFB; RGD1307832; RP13-122B23.3; RP23-132N23.4; NELF-B

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