This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component;of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival,;differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the;transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal;transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as;well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene.
CNTFR; ciliary neurotrophic factor receptor; ciliary neurotrophic factor receptor subunit alpha; CNTFR-alpha; CNTF receptor subunit alpha; MGC1774; GPAR-alpha; GPA receptor subunit alpha; growth-promoting activity receptor subunit alpha; growth promoting activity; cb549; fj33e02; sb:cb549; wu:fj33e02; si:bz76a6.1; si:dz248f2.1; si:rp71-76a6.1