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clps

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Official Full Name
colipase, pancreatic
Background
The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements.
Synonyms
CLPS; colipase, pancreatic; colipase; Colipase pancreatic; Pancreatic colipase preproprotein; OTTHUMP00000016271