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cir1

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Official Full Name
ubiquitin-conjugating enzyme E2 variant 1
Background
Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
Synonyms
UBE2V1; ubiquitin-conjugating enzyme E2 variant 1; UBE2V; CROC 1; CROC1; UEV 1; UEV1A; DNA-binding protein; TRAF6-regulated IKK activator 1 beta Uev1A; CIR1; UEV1; UEV-1; CROC-1; CROC-1B; im:7136154; zgc:123326; Druev1